Epigenetic changes in sites mapped to genes in children of fathers who smoked before the age of 15 years, suggests how fathers’ early teenage smoking may increase the risk of their future children developing asthma, obesity, and low lung function.
The study suggests how epigenetic mechanisms of pubertal paternal smoking may increase the risk of respiratory health across generations transmitted specifically through male germ cells. To the researcher’s knowledge, this epigenome-wide association study (EWAS), published in Clinical Epigenetics1 is the first of its kind to investigate the impact of fathers’ smoking in their teenage years on their offspring.
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