For infants and young children with acute wheezing, clinically significant improvements were observed when albuterol was administered through a valved holding chamber (VHC) with high in vitro drug delivery versus low in vitro drug delivery, a randomized trial from Finland showed. Among 80 children ages 6 to 48 months, those who used an inhaler with a VHC with high drug delivery had a significantly lower respiratory distress assessment instrument (RDAI) score compared with the low drug delivery group (2.7 vs 6.8 on a scale from 0 to 17, with higher levels indicating worse distress, P<0.001), reported Péter Csonka, MD, PhD, of Tampere University in Finland, and colleagues.
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